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norskBlar i forfatter "Steigen, Sonja Eriksson"
Viser treff 1-20 av 23
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APC mosaicism in a young woman with desmoid type fibromatosis and familial adenomatous polyposis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-01-24)Familial adenomatous polyposis (FAP) is usually caused by germline mutations in the adenomatous polyposis coli (APC) gene. The classic form is characterized by hundreds to thousands of adenomas in the colorectum and early onset colorectal cancer (CRC) if left untreated. FAP is also associated with multiple extra-colonic manifestations such as gastroduodenal polyps, osteomas, epidermoid cysts, fibromas ... -
Characterisation and prognostic value of tertiary lymphoid structures in oral squamous cell carcinoma
(Journal article; Tidsskriftartikkel; Peer reviewed, 2014-08-23)<p><i>Background -</i>Oral squamous cell carcinomas are often heavily infiltrated by immune cells. The organization of B-cells, follicular dendritic cells, T-cells and high-endothelial venules into structures termed tertiary lymphoid structures have been detected in various types of cancer, where their presence is found to predict favourable outcome. The purpose of the present study was to evaluate ... -
Characteristics and prognosis of primary treatment-naïve oral cavity squamous cell carcinoma in Norway, a descriptive retrospective study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-01-16)<i>Objectives</i> - Incidence of oral cavity squamous cell carcinomas is rising worldwide, and population characterization is important to follow for future trends. The aim of this retrospective study was to present a large cohort of primary oral cavity squamous cell carcinoma from all four health regions of Norway, with descriptive clinicopathological characteristics and five-year survival ... -
Clincal use of optical coherence tomography to identify angiographic silent stent thrombosis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2014)Objectives. Patients previously treated with coronary stents may suffer an acute coronary syndrome (ACS) without any evidence of thrombus formation on coronary angiography (CAG). This may be due to partial, nonocclusive stent thrombosis with microembolization. In this paper, we illustrate possible mechanisms both with optical coherence tomography (OCT) and histology. Design. We present two cases ... -
Clinicopathological characteristics of oral squamous cell carcinoma in Northern Norway: a retrospective study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2014) -
A combined histo-score based on tumor differentiation and lymphocytic infiltrate is a robust prognostic marker for mobile tongue cancer
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-30)We wanted to evaluate the prognostic value of common histopathological variables in a large cohort of patients with cancer in the mobile tongue as such information can be important for treatment stratification of the individual patient, especially for patients with low-stage disease. In addition, we wanted to investigate whether an alternative scoring model with fewer options would compromise the ... -
Deep learning-based image analysis reveals significant differences in the number and distribution of mucosal CD3 and γδ T cells between Crohn's disease and ulcerative colitis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-11-23)Colon mucosae of ulcerative colitis (UC) and Crohn's disease (CD) display differences in the number and distribution of immune cells that are difficult to assess by eye. Deep learning-based analysis on whole slide images (WSIs) allows extraction of complex quantitative data that can be used to uncover different inflammatory patterns. We aimed to explore the distribution of CD3 and γδ T cells in colon ... -
Do not be fooled by fancy mutations: inflammatory fibroid polyps can be harbor mutations similar to those found in GIST
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013)Goal. Surgeons that remove a typical polyp from the stomach or small intestine should be reluctant to accept a diagnosis of GIST just because there is a mutation in platelet-derived growth factor receptor alfa (PDGFRA). Background. A subtype of gastric and intestinal polyps is denoted as inflammatory fibroid polyp (IFP). In some of these cases a mutation in PDGFRA is found, leading to the diagnosis ... -
The effects of terlipressin and direct portacaval shunting on liver hemodynamics following 80% hepatectomy in the pig
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-15)Liver failure is the major cause of death following liver resection. Post-resection portal venous pressure (PVP) predicts liver failure, is implicated in its pathogenesis, and when PVP is reduced, rates of liver dysfunction decrease. The aim of the present study was to characterize the hemodynamic, biochemical, and histological changes induced by 80% hepatectomy in non-cirrhotic pigs and determine ... -
Endoscopic full-thickness dissection (EFTD) in the rectum: a case series
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-12-28)Background Rectal endoscopic full- thickness dissection (EFTD) using a fexible colonoscope is an alternative to the wellestablished trans-anal endoscopic microsurgery (TEM) and the trans-anal minimally invasive surgery (TAMIS) techniques for resecting dysplastic or malignant rectal lesions. This study evaluated EFTD safety by analyzing outcomes of the frst patients to undergo rectal EFTD at the ... -
Impact of KRAS, BRAF and microsatellite instability status after cytoreductive surgery and HIPEC in a national cohort of colorectal peritoneal metastasis patients
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-12-09)Background - Patients with metastatic colorectal cancer (mCRC) carrying BRAF (mutBRAF) or KRAS mutation (mutKRAS) have an inferior prognosis after liver or lung surgery, whereas the prognostic role in the context of peritoneal metastasis (PM) after cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) has been less investigated.<p> <p>Methods - In total, 257 patients ... -
Nephronectin promotes breast cancer brain metastatic colonization via its integrin-binding domains
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-07-22)This study demonstrates a role for the extracellular matrix protein nephronectin (NPNT) in promoting experimental breast cancer brain metastasis, possibly through enhanced binding to- and migration through brain endothelial cells. With the introduction of more targeted breast cancer treatments, a prolonged survival has resulted during the last decade. Consequently, an increased number of patients ... -
No significant histological or ultrastructural tendinosis changes in the hamsting tendon in patients with mild to moderate osteoarthritis of the knee?
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-20)Purpose To investigate the periarticular degenerative changes of the knee joint in association with osteoarthritis (OA). More tendinosis was expected to be found in the semitendinosus tendon in patients with knee OA than in patients without knee OA.<p> Methods Samples from 41 patients were included between January 2016 and October 2017. Twenty-one patients median age 53 (33–63) years with mild ... -
No significant histological or ultrastructural tendinosis changes in the hamstring tendon in patients with mild to moderate osteoarthritis of the knee?
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-05)Purpose - To investigate the periarticular degenerative changes of the knee joint in association with osteoarthritis (OA). More tendinosis was expected to be found in the semitendinosus tendon in patients with knee OA than in patients without knee OA.<p> <p>Methods - Samples from 41 patients were included between January 2016 and October 2017. Twenty-one patients median age 53 (33–63) years with ... -
Plectin as a prognostic marker in non-metastatic oral squamous cell carcinoma
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-08-26)<p>Background: Oral squamous cell carcinoma (OSCC) is associated with a poor 5-year survival rate. In general, patients diagnosed with small tumors have a fairly good prognosis, but some small tumors have an aggressive behavior leading to early death. There are at present no reliable prognostic biomarkers for oral cancers. Thus, to optimize treatment for the individual patient, there is a need ... -
Presence of high-endothelial venules correlates with a favorable immune microenvironment in oral squamous cell carcinoma
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-02-07)Oral squamous cell carcinomas are associated with a poor prognosis, which may be partly due to functional impairment of the immune response. Lymphocyte recruitment to the tumor site is facilitated by high-endothelial venules, whereas expression of programmed-death ligand 1 (PD-L1) can impair T-cell function. Thus, we hypothesize that these factors are important in shaping the immune response in oral ... -
Presence of high-endothelial venules correlates with a favorable immune microenvironment in oral squamous cell carsinoma
(Master thesis; Mastergradsoppgave, 2017-10-31)Oral squamous cell carcinomas (OSCC) are associated with a poor prognosis, which may be partly due to functional impairment of the immune response. Lymphocyte recruitment to the tumor site is facilitated by high-endothelial venules (HEV), whereas expression of programmed-death ligand 1 (PD-L1) can impair T cell function. Thus, we hypothesize that these factors are important in shaping the immune ... -
Presence of tumour high-endothelial venules is an independent positive prognostic factor and stratifies patients with advanced-stage oral squamous cell carcinoma
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-09-17)Background: Staging of oral squamous cell carcinoma is based on the TNM system, which has been deemed insufficient for prognostic purposes. Hence, better prognostic tools are needed to reflect the biological diversity of these cancers. Previously, high numbers of specialized blood vessels called high-endothelial venules have been reported to be associated with prolonged survival in patients with ... -
Tumor budding score predicts lymph node status in oral tongue squamous cell carcinoma and should be included in the pathology report
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-09-25)<i>Background</i> - The majority of oral cavity cancers arise in the oral tongue. The aim of this study was to evaluate the prognostic value of tumor budding in oral tongue squamous cell carcinoma, both as a separate variable and in combination with depth of invasion. We also assessed the prognostic impact of the 8th edition of the American Joint Committee on Cancer’s TNM classification (TNM8), where ... -
Tumor-associated macrophages and macrophage-related immune checkpoint expression in sarcomas
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-04-12)Early trials for immune checkpoint inhibitors in sarcomas have delivered mixed results, and efforts to improve outcomes now look to combinatorial strategies with novel immunotherapeutics, including some that target macrophages. To enhance our understanding of the sarcoma immune landscape, we quantified and characterized tumor-associated macrophage infiltration and expression of the targetable ...
